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Sioux City's Neighborhood Pharmacy

Hi there! We're Drugtown — your health is our happy place.

We're not your typical pharmacy. We know your name, we remember your prescriptions, and we actually enjoy making sure you're taken care of. Stop by and say hello — we've got your back.

Friendly pharmacist at Drugtown counter helping a customer
Trusted Locally Caring for Sioux City families
Prescription Ready
Licensed Pharmacists
Most Insurance Accepted
Fast Prescriptions
Personalized Care
Right on Pierce St.

More than just prescriptions

From filling your daily meds to keeping your family up to date on shots, Drugtown is here for all your health needs — with a smile.

Prescription Filling

We handle new and refill prescriptions with care and accuracy. Quick turnarounds, friendly check-ins, and zero judgment — just good service.

Immunizations & Vaccines

Flu shots, travel vaccines, shingles, pneumonia — we've got you covered. Walk-ins welcome, or give us a call to schedule your visit.

Health Screenings

Blood pressure checks, A1C testing, and other preventive screenings right here at the pharmacy. Staying on top of your health shouldn't be hard.

Insurance & Pricing Help

Not sure about your coverage? We'll check your insurance, find the best price, and work with you so prescriptions don't become a financial worry.

Medication Therapy Reviews

Too many pills? We'll sit down with you, review everything you're taking, and talk with your doctor about simplifying your regimen.

Personal Health Conversations

Questions about a new med? Worried about side effects? We're here to listen and help — no rush, no rush hour. Your health questions matter to us.

Drugtown pharmacy storefront on Pierce Street in Sioux City Inside Drugtown pharmacy with friendly staff

We're your neighbors, your pharmacists, and your health advocates.

Drugtown has been a part of the Sioux City community for years, and we take that seriously. We're the kind of place where you're not a prescription number — you're a person we look out for.

Our team of licensed pharmacists brings real experience and genuine warmth to everything we do. Whether it's catching a drug interaction your doctor missed, helping you find a more affordable alternative, or just having a good conversation while you wait, we show up for our customers every single day.

Licensed pharmacists on staff
Friendly, no-rush environment
Community-focused since day one
Convenient Sioux City location

What makes us different (and we're proud of it)

There are plenty of places to fill a prescription. Here's why Sioux City keeps coming back to Drugtown.

Real Relationships

We learn your story, your meds, and your concerns. You walk in, we know you — not your insurance ID.

Speed That Matters

Your time is valuable. We work hard to get your prescription ready fast, without cutting corners on accuracy.

Advocacy First

We'll flag interactions, suggest alternatives, and call your doctor when something doesn't add up. You deserve an advocate.

Right Here in Town

Located right on Pierce Street, we're easy to find, easy to park, and right in the heart of Sioux City.

Come say hello

We're right here in Sioux City, and we'd love to meet you. Stop by or give us a ring — we're always happy to help.

Get in Touch

Address 2627 Pierce St
Sioux City, IA 51104-3727
Hours Monday – Friday: 9:00 AM – 7:00 PM

Weekly Schedule

Monday 9:00 AM – 7:00 PM
Tuesday 9:00 AM – 7:00 PM
Wednesday 9:00 AM – 7:00 PM
Thursday 9:00 AM – 7:00 PM
Friday 9:00 AM – 7:00 PM
Saturday Closed
Sunday Closed

Your health deserves a pharmacy that actually cares.

Give Drugtown a try — we promise you'll feel the difference the moment you walk through our doors. No appointment needed for most services.

Is this your business?This is my business